References and Papers

Selected Peer Reviewed Publications:

  1. Radovic-Moreno AF, Chernyak N, Mader CC, Nallagatla S, Kang RS, Hao L, Walker DA, Halo TL, Merkel TJ, Rische CH, Anantatmula S, Burkhart M, Mirkin CA, Gryaznov SM. Immunomodulatory Spherical Nucleic Acids. Proc. Natl. Acad. Sci. USA. 2015 112: 3892-3897.
  2. Banga RJ, Chernyak N, Narayan SP, Nguyen ST, Mirkin CA. Liposomal Spherical Nucleic Acids. J. Am. Chem. Soc. 2014 136: 9866-9869.
  3. Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, Stegh AH. Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. Sci. Transl. Med. 5, 209ra152 (2013).
  4. Choi CHJ, Hao L, Narayan SP, Auyeung E, Mirkin CA. Mechanism for the Endocytosis of Spherical Nucleic Acid Nanoparticle Conjugates. Proc. Natl. Acad. Sci. USA. 2013 110(19):7625-7630.
  5. Weintraub K. The New Gold Standard. Nature 2013 495:S14-S16.
  6. Zhang K, Hao L, Hurst SJ, Mirkin CA. Antibody-Linked Spherical Nucleic Acids for Cellular Targeting. J. Am. Chem. Soc. 2012 134:16488-16491.
  7. Mirkin CA. An Interview with Chad Mirkin: Nanomedicine Expert. Nanomedicine 2012 7:635-638.
  8. Zheng D, Giljohann DA, Chen DL, Massich MD, Wang XQ, Iordanov H, Mirkin CA, Paller AS. Topical Delivery of siRNA-based Spherical Nucleic Acid Nanoparticle Conjugates for Gene Regulation. Proc. Natl. Acad. Sci. USA. 2012 109:11975-80.
  9. Young KL, Scott AW, Hao L, Mirkin SE, Liu G, Mirkin CA. Hollow Spherical Nucleic Acids for Intracellular Gene Regulation Based upon Biocompatible Silica Shells. Nano Lett. 2012 12:3867-71.
  10. Cutler JI, Auyeung E, Mirkin CA. Spherical Nucleic Acids. J. Am. Chem. Soc. 2012 134:1376-1391.
  11. Zhang XQ, Xu XY, Lam R, Giljohann DA, Ho D, Mirkin CA. Strategy for Increasing Drug Solubility and Efficacy through Covalent Attachment to Polyvalent DNA - Nanoparticle Conjugates. ACS Nano. 2011 5:6962-6970.
  12. Hao LL, Patel PC, Alhasan AH, Giljohann DA, Mirkin CA. Nucleic Acid-Gold Nanoparticle Conjugates as Mimics of microRNA. Small. 2011 7:3158-3162.
  13. Patel PC, Hao LL, Yeung WS, Mirkin CA. Duplex End Breathing Determines Serum Stability and Intracellular Potency of siRNA-Au NPs. Mol. Pharmaceutics. 2011 8:1285-1291.
  14. Cutler JI, Zhang K, Zheng D, Auyeung E, Prigodich AE, Mirkin CA. Polyvalent Nucleic Acid Nanostructures. J. Am. Chem. Soc. 2011 133:9254-9257.
  15. McMahon KM, Mutharasan RK, Tripathy S, Veliceasa D, Bobeica M, Shumaker DK, Luthi AJ, Helfand BT, Ardehali H, Mirkin CA, Volpert O, Thaxton CS. Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery. Nano Lett. 2011 11:1208-1214.
  16. Prigodich AE, Alhasan AH, Mirkin CA. Selective Enhancement of Nucleases by Polyvalent DNA-Functionalized Gold Nanoparticles. J. Am. Chem. Soc. 2011 133:2120-2123.
  17. Rink JS, McMahon KM, Chen X, Mirkin CA, Thaxton CS, Kaufman DB. Transfection of Pancreatic Islets Using Polyvalent DNA-functionalized Gold Nanoparticles. Surgery 2010 148:335-345.
  18. Patel PC, Giljohann DA, Daniel WL, Zheng D, Prigodich AE, Mirkin CA. Scavenger Receptors Mediate Cellular Uptake of Polyvalent Oligonucleotide-Functionalized Gold Nanoparticles. Bioconju. Chem. 2010 21:2250-2256.
  19. Massich MD, Giljohann DA, Schmucker AL, Patel PC, Mirkin CA. Cellular Response of Polyvalent Oligonucleotide-Gold Nanoparticle Conjugates. ACS Nano 2010 4:5641-5646.
  20. Mirkin CA. The Polyvalent Gold Nanoparticle Conjugate - Materials Synthesis, Biodiagnostics, and Intracellular Gene Regulation. MRS Bull. 2010 35:532-539.
  21. Giljohann DA, Seferos DS, Massich MD, Daniel WL, Patel PC, Mirkin CA. Gold Nanoparticles for Biology and Medicine. Angew. Chem. Int. Ed. 2010 49:3280-3294.
  22. Seferos DS, Prigodich AE, Giljohann DA, Patel PC, Mirkin CA. Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids. Nano Lett. 2009 1:308-311.
  23. Giljohann DA, Seferos DS, Prigodich AE, Patel PC, Mirkin CA. Gene Regulation with Polyvalent siRNA-Nanoparticle Conjugates. J. Am. Chem. Soc. 2009 131:2072-2073.
  24. Prigodich AE, Seferos DA, Massich M D, Giljohann DA, Lane BC, Mirkin CA. Nano-Flares for mRNA Regulation and Detection. ACS Nano. 2009 3:2147-2152.
  25. Dhar S, Daniel WL, Giljohann DA, Mirkin CA, Lippard, SJ. Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum (IV) Warheads. J. Am. Chem. Soc. 2009 131:14652-14653.
  26. Patel PC, Giljohann DA, Seferos DS, Mirkin CA. Peptide Antisense Nanoparticles. Proc. Natl. Acad. Sci. USA. 2008 105:17222-17226.
  27. Seferos DS, Giljohann DA, Rosi NL, Mirkin CA. Locked Nucleic Acid-Nanoparticle Conjugates. ChemBioChem. 2007 8:1230-1232.
  28. Giljohann DA, Seferos DS, Patel PC, Millstone JE, Rosi NL, Mirkin CA. Oligonucleotide Loading Determines Cellular Uptake of DNA-Modified Nanoparticles. Nano Lett. 2007 7:3818-3821.
  29. Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean A, Han MS, Mirkin CA. Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation. Science. 2006 312:1027-1030.
  30. Mirkin, CA, Letsinger, RL, Mucic, RC, Storhoff, JJ. A DNA-Based Method for Rationally Assembling Nanoparticles into Macroscopic Materials. Nature. 1996 382:607-609.